https://stv.tv/news/uk/1421517-aspirin-shows-promising-potential-as-alzheimer-s-treatment-say-scientist/
Citando:
"Low dose aspirin may help cells in the brain to clear away a toxic protein molecule at the core of Alzheimer's, early research suggests.
Scientists showed the common pain killer stimulated cellular machinery that acts as a waste disposal system to keep the brain "clean".
Genetically engineered mice given the drug had reduced levels of a key hallmark of Alzheimer's in their brains, sticky clumps of beta amyloid peptide."
(...)
": "Clinical trials of aspirin have already been performed in patients with Alzheimer's disease.
"The drug had no beneficial effects on outcome measures and was associated with an increased risk of gastrointestinal haemorrhage."
The American researchers pointed out the mechanism appeared to be dependent on a protein called PPAR-alpha, levels of which fell significantly with age.
This might explain why trials looking at the effects of aspirin on elderly Alzheimer's patients had produced disappointing results, they said."
