Café e protecção Cancro Próstata?

E não será da cafeína:
https://www.noticiasaominuto.com/lifestyle/1365037/as-duas-bebidas-quentes-e-deliciosas-que-reduzem-cancro-da-prostata

O levantamento não recomenda o aumento do consumo por não ser totalmente conclusivo.

Citando:
"um levantamento realizado nos Estados Unidos e publicado, recentemente, pela revista Journal of the National Cancer Institute (JNCI), revelou que três ou mais chávenas diárias de receitas de café tipicamente italianas, como moka, expresso, além de combinações que adicionam leite, como café latte, macchiato e o famoso cappuccino, podem reduzir, significativamente, o risco de cancro da próstata. “Esta informação foi obtida por meio de recolha de dados epidemiológicos locais. Porém, é possível, em certa medida, considerarmos esta pesquisa como um parâmetro também para o nosso dia-a-dia”, afirma o oncologista do Hospital do Coração (HCor), Auro Del Giglio."

Investigação: Vírus do Zika contra cancro da próstata?

https://canaltech.com.br/saude/virus-da-zika-pode-ser-a-arma-contra-o-cancer-de-prostata-155211/

Citando:
"Liderados pelo professor da universidade Rodrigo Ramos Catharino, os pesquisadores descobriram que esse agente pode ser uma arma contra o câncer de próstata. Através de experimentos feitos com o vírus in vitro, os cientistas perceberam que o zika é capaz de inibir a proliferação das células tumorais, mesmo após ser inativado por altas temperaturas, como divulgado em artigo na revista Scientific Reports."

Auxiliares de decisão e Cancro da Próstata?

O que fazer com o diagnóstico?
https://lifestyle.sapo.pt/saude/noticias-saude/artigos/auxiliares-de-decisao-ajudam-homens-a-decidir-sobre-rastreio-do-cancro-da-prostata

Citando:
"“O acesso a ‘auxiliares de decisão’ aumenta significativamente o conhecimento dos pacientes, reduz a indecisão e fomenta um papel ativo por parte dos homens que têm de decidir se realizam ou não o PSA – uma análise que pode identificar cancro da próstata, mas que apresenta diversos riscos, como sobrediagnóstico e efeitos adversos do sobretratamento, como disfunção erétil e incontinência urinária”, esclarecem os investigadores."

Cancro da próstata

A história de Brian Custer:
https://www.menshealth.com/health/a23025236/brian-custer-prostate-cancer/

Citando:
"He says his fitness routine was crucial to his rapid recovery. "My marital arts instructor came over to visit and said, 'You’re a martial artist, you're mentally tougher and physically tougher than anybody. He had me using 2-pound and 5-pound little kettle bells. He said, 'Even if you have to sit on your couch and arm curl these, try to do these little squats with 2 pounders. So that's what I did."

Custer also did Kegel exercises to regain strength in his pelvis and help him fend off incontinence, a common side effect of prostate cancer surgery. He was initially worried that he would experience erectile dysfunction, another common side effect of the procedure, but "my doctor was very honest that he wasn't going to snip any nerves, that he wanted me to have a very happy and healthy sex life," he says."

Risco acrescido de cancro para quem janta tarde?

Pessoas que comem regularmente menos de 2h antes de se deitar, 25% de risco acrescido?
https://www.telegraph.co.uk/health-fitness/body/trouble-modern-dinner-do-better/

Citação:
"But according to a new study evening snacking and eating dinner too late can increase the risk of breast and prostate cancer, by disrupting the body’s internal clock and metabolism."

63 mutações associadas a Cancro da Próstata

http://www.dailymail.co.uk/health/article-5830677/amp/Prostate-cancer-breakthrough-DNA-test-identifies-men-likely-develop-disease.html

Estudo: uso do PSA para cancro próstata

https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/102618-twenty-year-risk-of-prostate-cancer-death-by-midlife-prostate-specific-antigen-and-a-panel-of-four-kallikrein-markers-in-a-large-population-based-cohort-of-healthy-men.html

Citando:
"A prespecified statistical model based on four kallikrein markers (commercially available as the 4Kscore) reclassified many men with modestly elevated PSA, to have a low long-term risk of prostate cancer death. Men with elevated PSA but low scores from the four-kallikrein panel can be monitored rather than being subject to biopsy.

Men with elevated prostate-specific antigen (PSA) are often referred for prostate biopsy. However, men with elevated PSA but low scores from the four-kallikrein panel can be monitored rather than being subject to biopsy."

6 factores de risco para o cancro da próstata

https://www.express.co.uk/life-style/health/924382/cancer-symptoms-prostate-signs-causes

Citando:
"[Factors] include:

Age - risk rises as you get older and most cases are diagnosed in men over 50 years of age.

Ethnic group – prostate cancer is more common among men of African-Caribbean and African descent than in men of Asian descent.

Family history – having a brother or father who developed prostate cancer under the age of 60 seems to increase the risk of you developing it. Research also shows that having a close female relative who developed breast cancer may also increase your risk of developing prostate cancer.

Obesity – recent research suggests that there may be a link between obesity and prostate cancer.

Exercise – men who regularly exercise have also been found to be at lower risk of developing prostate cancer.

Diet – research is ongoing into the links between diet and prostate cancer. There is evidence that a diet high in calcium is linked to an increased risk of developing prostate cancer."

Cancro da próstata e ejaculação?

Um estudo que indica menor incidência de cancro da próstata:
https://www.thesun.co.uk/living/3946845/orgasms-avoid-cancer-men-prostate-research/

Citando:
"In fact, in a study of almost 32,000 men published in the journal of European Urology, researchers found high levels of sexual activity can reduce the risk of contracting prostate cancer by 33 per cent.

The optimum number is 21 ejaculations per month which is equal to 252 times annually — or almost 70 per cent of days in a year.

Experts aren’t exactly sure why ejaculation lowers the risk of prostate cancer, but they speculate it might help flush out cancer-causing toxins.

In the UK alone, 40,000 men are diagnosed with prostate cancer every year – and there are 11,000 deaths-a-year.

It is also the third deadliest cancer in the UK and the disease develops slowly, meaning many men don’t know they have it for several years.

Prostate cancer currently kills 10,900 men a year and Prostate Cancer UK warn that this number could surge to 15,000 a year by 2026."

Homens altos mais propensos a cancro da próstata agressivo

https://www.theguardian.com/society/2017/jul/13/tall-men-at-bigger-risk-of-aggressive-prostate-cancer-study-suggests

Citando:
"Tall men are at greater risk of contracting aggressive prostate cancer and of dying from the disease, the findings of a large study suggest.

British scientists found that every 10cm increment in height increased the chance of developing high-grade prostate cancer by 21% and the risk of death from the disease by 17%. They also found that obesity raised the risk of aggressive prostate cancer."

Ai o cancro da próstata e fazer aquela coisa 21 vezes por mês...

https://news.google.pt/news/amp?caurl=http%3A%2F%2Fwww.dailymail.co.uk%2Fhealth%2Farticle-4666798%2FEjaculating-significantly-reduces-risk-cancer.html#pt0-294736
Citando:
"
-This is compared to men who ejaculate just four-to-seven times a month
-Ejaculation is protective regardless of whether it's through sex or masturbation
-Past research suggests ejaculation rids the gland of cancer-causing substances
-It may also help to ease inflammation, which is a known cause of the condition
-Researchers from Harvard University analyzed 31,925 men for 18 years 

Ejaculating at least 21 times a month significantly reduces a man's risk of prostate cancer, new research reveals. "

Novas análises ao sangue podem ajudar a personalizar o tratamento do Cancro da Próstata...

... cujo tratamento mais cego e radical pode levar a todos os efeitos secundários que homem algum gosta (incontinência, impotência e mais coisas acabadas em "ência"...):

New blood test could see personalised prostate cancer treatment | Society | The Guardian

Citando:
"A new three-in-one blood test could pave the way to precision-personalised treatment for advanced prostate cancer, say scientists.

The test has the potential to transform the way the disease is tackled by targeting specific gene mutations, it is claimed.

By looking for cancer DNA in blood samples, researchers were able to identify men with defective BRCA genes who were likely to benefit from a class of drugs called Parp inhibitors.

Breast cancer drug that can extend lives approved for NHS use
They also used the test to monitor DNA in the blood after treatment started, so patients who were not responding could quickly be switched to an alternative therapy.
Finally, the same test was used to pick up signs of evolving cancer showing the first signs of drug resistance."

Cancro Próstata poderá ser prevenido por combinação de Açafrão, Uvas Tintas e Maçãs (estudo em ratos)

Turmeric, red grape and apple can prevent prostate cancer | Daily Mail Online

Citando:

"Eating turmeric [açafrão], red grapes [uvas tintas] and apples [maçãs] could help to 'starve' prostate cancer cells and protect men from the disease

• Mice who were fed the ingredients were able to kill off prostate cancer cells
• When eaten in combination, the ingredients can 'starve' off cancer cells
• Foods do this by stopping tumours from taking up compounds they need to grow
• Prostate cancer is the second most common type of cancer among males"

Gatos podem levar a cancro da próstata?

1/3 dos gatos no RU são portadores de um parasita (toxoplasma gondii) que se infectar os donos leva a inflamação crónica que facilita o aparecimento de cancro da próstata:
http://www.dailymail.co.uk/news/article-4526256/Cats-cause-prostate-cancer-men-spreading-parasite.html

Citando:
"A parasite spread by cats could be a factor in causing prostate cancer in men
Scientists found microscopic bug Toxoplasma gondii can trigger inflammation
Chronic inflammation is known to double the risk of developing the cancer
The parasite is carried by cats, is shed in their faeces therefore can spread easily
(...)
Humans can then be infected by drinking contaminated water, eating unwashed vegetables or handling cat litter trays.

More than 46,000 men are diagnosed with prostate cancer each year in the UK.

Dr Travis Jerde, a professor of toxicology at Indiana University and one of the study authors, said: ‘No one should be getting rid of their cat because of this study, but precautions should be taken when working or playing in areas where cats may have gone to the bathroom – like a garden or sandbox.’"

Avanços na distinção entre cancros da próstata agressivos e os não agressivos

Uns "tratam-se" (e deixam muitas pessoas incontinentes ou impotentes) outros "deixam-se andar". Por isso convém saber quais são quais:
http://www.express.co.uk/life-style/health/773513/prostate-cancer-symptoms-test-treatment-UK

Citando:
"Professor Vincent Moulton, co-author on the study said experts are trying to group cancers which show common traits in a bid to improve classification of tumours.

"These were categorised by low expression of a core set of 45 genes, many encoding proteins involved in the structure of cells, transport of ions (charged molecules) and cell adhesion,” he said.

“This was common across the samples of cancers known to have a poor patient prognosis."

The research is reported in the journal European Urology Focus."

Tratamento novo para cancro da próstata (bactérias tóxicas activadas por luz)

Algo ainda em ensaios com um enorme potencial (dado que todas as opções actuais envolvem riscos elevadíssimos de efeitos secundários terríveis para os homens - impotência e incontinência):
http://www.bbc.com/news/health-38304076


Citando:
"The new treatment uses a drug, made from bacteria that live in the almost total darkness of the seafloor and which become toxic only when exposed to light.
Ten fibre optic lasers are inserted through the perineum - the gap between the anus and the testes - and into the cancerous prostate gland.
When the red laser is switched on, it activates the drug to kill the cancer and leaves the healthy prostate behind."

Alternativa de biópsia à próstata com maior taxa de detecção

Evolução interessante uma vez que a biópsia tinha efeitos secundarios possíveis como disfunção eréctil e uma taxa de detecção correcta (de tumores agressivos que requerem atenção imediata) muito baixa:
http://www.bbc.com/news/health-38665618
Citando:
"The biggest leap in diagnosing prostate cancer "in decades" has been made using new scanning equipment, say doctors and campaigners.
Using advanced MRI nearly doubles the number of aggressive tumours that are caught.
And the trial on 576 men, published in the Lancet, showed more than a quarter could be spared invasive biopsies, which can lead to severe side-effects.
The NHS is already reviewing whether the scans can be introduced widely.
Prostate cancer is the most common cancer in British men (...)"
"If men have high prostate specific antigen (PSA) levels in the blood, they go for a biopsy.
Twelve needles then take random samples from the whole of the prostate.
It can miss a cancer that is there, fail to spot whether it is aggressive, and cause side-effects including bleeding, serious infections and erectile dysfunction.
"Taking a random biopsy from the breast would not be accepted, but we accept that in prostate," said Dr Hashim Ahmed, a consultant and one of the researchers.
Around 100,000 to 120,000 men go through this every year in the UK."
(...)
"93% of aggressive cancers were detected by using the MRI scan to guide the biopsy compared with just 48% when the biopsy was done at random."

Terapia não invasiva de cancro da próstata (laser)...

... E a importância da biodiversidade (bactérias marinhas foram a inspiração):


http://m.scmp.com/tech/innovation/article/2056369/new-form-therapy-involving-lasers-could-transform-way-prostate


Citando:
"A clinical trial has shown that a new, non-surgical method of treatment for low-risk prostate cancer can effectively kill cancer cells whilst at the same time preserving healthy tissue.
The new treatment is called vascular-targeted photodynamic therapy, or VTP. According to University College London Hospitals (UCLH), the treatment uses a light-sensitive drug, which is injected into the bloodstream. A laser then activates the drug, which eradicates tumour tissue in the prostate.



The drug used is called WST11 and comes from bacteria found at the bottom of the ocean. These bacteria have evolved to turn light into energy in a very efficient way. This trait has been exploited to develop WST11, which UCLH describes as “a compound that releases free radicals to kill surrounding cells when activated by laser light.”"

Terapia com testosterona em cancro da próstata?

Resultados promissores em que em vez de suprimir os níveis de testosterona aos pacientes com cancro da próstata como se costuma se dão doses elevadas seguidas de um intervalo. A testosterona afecta o DNA da células cancerosas tornando-as "senis" (deixando de causar grandes problemas):
http://www.seeker.com/shocking-prostate-tumor-with-testosterone-cures-man-of-cancer-2124502536.html


Citando:
"A radical therapy is showing promising results in the fight against prostate cancer. At a medical symposium in Europe this week, researchers reported that "shocking" prostate tumors by rapidly elevating and then dropping men's testosterone levels interfered with the cancer's growth."
(...)
"Technically referred to as bipolar androgen therapy (BAT), the treatment is aimed at patients who have metastatic prostate cancer that's otherwise resistant to treatment by chemical or surgical castration. It's based on the idea, supported by previous studies, that high doses of testosterone can interfere with cancer cell division in some cases, and actually cause some cancer cells to make breaks in their own DNA."

Os níveis de PSA e os exames e intervenções à próstata

Um relato em primeira-mão de uma história que começou com níveis de PSA elevados (testados por análises ao sangue):
http://m.huffpost.com/uk/entry/12751516


Citando:
"[I] had a PSA level of 16.  Now, PSA (prostate specific antigen, measured in nanograms per millilitre of blood) can give both false negatives and false positives.  Normal levels of PSA in the blood are between 0-2.5 ng/ml. Higher than normal levels, greater than 2.5, can be caused by cancer or by benign, non-cancerous conditions such as an enlarged prostate, prostate inflammation, infection, or trauma. But all elevated readings of PSA should be investigated."