Privação do sono e impacto nos genes

http://www.bbc.com/news/health-21572686

Citação:
"So researchers [2013] at the University of Surrey analysed the blood of 26 people after they had had plenty of sleep, up to 10 hours each night for a week, and compared the results with samples after a week of fewer than six hours a night.

More than 700 genes were altered by the shift. Each contains the instructions for building a protein, so those that became more active produced more proteins - changing the chemistry of the body.

Meanwhile the natural body clock was disturbed - some genes naturally wax and wane in activity through the day, but this effect was dulled by sleep deprivation.

Prof Colin Smith, from the University of Surrey, told the BBC: "There was quite a dramatic change in activity in many different kinds of genes."

Areas such as the immune system and how the body responds to damage and stress were affected.

Prof Smith added: "Clearly sleep is critical to rebuilding the body and maintaining a functional state, all kinds of damage appear to occur - hinting at what may lead to ill health.

"If we can't actually replenish and replace new cells, then that's going to lead to degenerative diseases.""

Privação do sono faz cérebro comer-se a si próprio?

Já se sabia que não dormir nos frita o cérebro (entre aspas), agora há um estudo (em ratos):
https://www.joe.ie/news/scientific-research-shows-harmful-effect-sleep-deprivation-brain-589863

Citando:
"This may cause brain cells to eat other parts of the brain, a new study has found.

The brain contains cells known as astrocytes, which work to clear away worn-out brain cells.

However, researchers at the Marche Polytechnic University in Italy recently discovered that astrocytes work at a higher rate in a sleep-deprived brain, according to New Scientist, potentially causing long-term damage.

The researchers compared the brains of mice that had been allowed to sleep for as long as they wanted with the brains of mice that were kept awake an additional eight hours.

A third group of mice was kept awake for a number of days to induce chronic sleep deprivation.

It was found that astrocytes were 6% active in the synapses (junctions which link nerve cells in the brain) of well-rested mice, compared with activity of around 8% in the mice  which had been kept awake for eight hours.

The mice that were chronically sleep-deprived showed astrocyte activity of around 13.5%, over double that of the well-rested mice.

"We show for the first time that portions of synapses are literally eaten by astrocytes because of sleep loss," said lead researcher Michele Bellesi."

Uma noite de privação do sono afecta coração (turnos)

http://www.telegraph.co.uk/science/2016/12/02/sleep-deprivation-puts-strain-heart-scientists-prove/


Citando:
"For the first time, we have shown that short-term sleep deprivation in the context of 24-hour shifts can lead to a significant increase in cardiac contractility, blood pressure and heart rate," said study author Dr Daniel Kuetting, of the University of Bonn in Bonn, Germany"