Ibuprofen e outros anti-inflamatórios (sem esteróides) associados a problemas cardíacos

Estes medicamentos são de venda livre no RU sendo usados para a dor (apesar de existirem alternativas com menos riscos):
http://m.belfasttelegraph.co.uk/news/uk/ibuprofen-linked-to-increased-risk-of-cardiac-arrest-35533110.html

Citando:
"He said: "Allowing these drugs to be purchased without a prescription, and without any advice or restrictions, sends a message to the public that they must be safe.

"The findings are a stark reminder that NSAIDs are not harmless.

"Diclofenac and ibuprofen, both commonly used drugs, were associated with significantly increased risk of cardiac arrest.

"NSAIDs should be used with caution and for a valid indication. They should probably be avoided in patients with cardiovascular disease or many cardiovascular risk factors."
(...)
"The most common cause of a cardiac arrest is a life-threatening abnormal heart rhythm called ventricular fibrillation (VF).

It causes electrical activity in the heart to become so chaotic that the organ ceases to pump rhythmically and quivers or "fibrillates" instead. Without immediate treatment to keep the circulation going, death occurs in minutes.

Sales of over-the-counter painkillers amounted to almost £600 million in the UK in 2015, according to The Pharmaceutical Journal."

Efeito de anti-inflamatórios (não esteróides) em dores de costas é negligenciável

... E não compensa o acrescido risco de problemas gastro-intestinais (úlceras, etc.). Tome o seu placebo favorito antes:
https://www.theguardian.com/society/2017/feb/03/back-pain-medications-have-little-benefit-and-may-cause-harm-research
Citando:
"Widely used anti-inflammatory drugs such as ibuprofen have little more benefit than a placebo when it comes to treating back pain, a comprehensive review has found.
Researchers analysed 35 peer-reviewed trials on the use of nonsteroidal anti-inflammatory drugs [NSAIDs] such as ibuprofen for back pain, reviewing data from 6,065 patients.
They found that none of the analgesics offered anything more than a mild relief for back-pain sufferers, and the effect was too small to be considered clinically important.

The comprehensive review, published in the journal Annals of the Rheumatic Diseases, found while the drugs offered little to no benefit, patients taking them were 2.5 times more likely to suffer from gastrointestinal problems such a stomach ulcers and bleeding."

Evitar medicar crianças com febre moderada?

Deve evitar-se medicar crianças com febre moderada? Aparentemente, sim. 

"Parents should not give children with a mild fever regular spoonfuls of paracetamol and ibuprofen, doctors advise today":

http://www.telegraph.co.uk/news/health/news/8351085/Parents-warned-against-giving-paracetamol-and-ibuprofen-for-mild-fever.html

Ibuprofen (Brufen) em altas doses e enfartes?

Agência Europeia do Medicamento alerta para o aumento dos riscos de problemas cardiovasculares (enfarte):

http://www.tvi24.iol.pt/sociedade/brufen/ibuprofeno-em-altas-doses-pode-provocar-enfarte

Toma prolongada de analgésicos em mulheres associada a perda de audiçao? (6 anos - NHS)

Citando:
"Women who take paracetamol or ibuprofen just twice a week could be damaging their hearing permanently," the Daily Mail reports.
A US study found an association between the long-term use of these widely used painkillers and reported hearing loss.
Researchers calculated just over 1 in 20 (5.5%) hearing loss cases in their study could have been the result of painkiller use.
But they say it's not possible for this study to prove the drugs caused the hearing problems.
Previous studies have linked aspirin, paracetamol, and non-steroidal anti-inflammatory drug (NSAID) types of painkiller, such as ibuprofen, with hearing loss."

Efeitos secundários de Ibuprofen (Brufen)? (analgésico)

Efeitos secundários de Ibuprofen (Brufen)? A lista de efeitos secundários é sempre assustadora nestes medicamentos ditos comuns (já leram a bula?). Eis alguém a quem um ipobrufen fez mal:


http://www.dailymail.co.uk/femail/article-4022112/It-truly-horrendous-mother-took-ibuprofen-common-cold-ended-hospital-INTERNAL-BLEEDING-despite-sticking-recommended-dose.html


Sobre o medicamento (NHS):
http://www.nhs.uk/Conditions/Painkillers-ibuprofen/Pages/Introduction.aspx

Anti-inflamatório Ibuprofen e redução de cancro do pulmão (fumadores)

Se se quiser ignorar os efeitos secundários, parece que o ibuprofeno - em pequenas doses - diminui a probabilidade de os fumadores contrairem cancro do pulmão:
http://www.dailymail.co.uk/health/article-4009958/Regular-doses-ibuprofen-lowers-smokers-risk-lung-cancer-48.html
Citando:
"Regular [small] doses of ibuprofen 'lowers smokers' risk of lung cancer by 48%'"

@2016-12-28: Editado para Ibuprofen